Archive for the ‘Ankylosis Spondylitis’ Category
According to the Arthritis Foundation nearly 46 million Americans suffer from painful arthritis. Are you one of them? It is one of the most prevalent chronic health problems and the nation’s leading cause of disability among Americans over the age of 15.
If you are one of the 46 million people battling arthritis you know that it limits everyday activities that others take for granted such as walking, dressing and bathing. Women are affected more greatly than men, but even children are at risk. Of the people with doctor-diagnosed arthritis 24.3 million are women, 17.1 million are men and nearly 300,000 are children.
Arthritis sufferers will tell you that the condition can come in many different shapes and forms affecting each individual differently. Arthritis causes pain, loss of movement and sometimes swelling. Here are some types of arthritis as described by the Arthritis Foundation:
Osteoarthritis: A degenerative joint disease in which the cartilage that covers the ends of bones in the joint deteriorates, causing pain and loss of movement as bone begins to rub against bone. It is the most prevalent form of arthritis. Rheumatoid arthritis: An autoimmune disease in which the joint lining becomes inflamed as part of the body’s immune system activity. Rheumatoid arthritis is one of the most serious and disabling types, affecting mostly women. Gout: It is usually the result of a defect in body chemistry. This painful condition most often attacks small joints, especially the big toe. Fortunately, gout almost always can be completely controlled with medication and changes in diet. Ankylosing spondylitis: A type of arthritis that affects the spine. As a result of inflammation, the bones of the spine grow together. Juvenile arthritis: A general term for all types of arthritis that occur in children. Children may develop juvenile rheumatoid arthritis or childhood forms of lupus, ankylosing spondylitis or other types of arthritis. Systemic lupus erythematosus (lupus): A serious disorder that can inflame and damage joints and other connective tissues throughout the body. Scleroderma: A disease of the body’s connective tissue that causes a thickening and hardening of the skin. Fibromyalgia: A condition in which widespread pain affects the muscles and attachments to the bone. It affects mostly women.
Half of the Americans with arthritis don’t think anything can be done to help them. But Flexcin is helping thousands of people around the nation and even the world find relief in a safe and all-natural solution. The primary component of Flexcin™ is CM8™ (cetyl myristoleate). Of all the ingredients in Flexcin, CM8™ is the most powerful. CM8™ functions in three different ways. First, it acts as a highly effective lubricant in the joints, muscles and other tissues, allowing them to move smoothly. Decrease or loss of morning stiffness is commonly noted shortly after commencing treatment. Next, CM8™ functions as an anti-inflammatory. Relief from swollen joints is often seen after the 4th or 5th week of treatment. Third, it is also an immune system modulator, which can be effectual against autoimmune diseases, such as arthritic conditions. CM8™ relieves joint pain at its source, reducing inflammation and irritation of the joints and tissues. It also has been helpful for many sufferers of muscle tension and fibromyalgia. All of these characteristics make CM8™ the most important ingredient in Flexcin.
In addition, Flexcin is proudly manufactured in the United States in a state of the art facility under the strict guidelines of the U.S. Food and Drug Administration’s Good Manufacturing Practices, or G.M.P. Before you buy any drug, medical food or dietary supplement, always ask whether it was manufactured under FDA GMP Standards.
Parts of this article were taken from the Arthritis Foundation’s website at www.arthritis.org.
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Reactive arthritis, referred to also as Reiter’s syndrome although this name is lapsing, is an arthritic condition related to infections such as Salmonella in the gastro-intestinal system and Chlamydia in the genito-urinary system. Reactive arthritis has a strong link with a human leucocyte antigen known as HLAB27 which is well known to be related to another arthritic condition called ankylosing spondylitis. This link puts both these conditions into a group classified as seronegative spondyloarthropathies. The arthritis usually occurs with infections such as urethritis or conjunctivitis but can occur also without them.
Once a person has an infection of the genitourinary system or the gastrointestinal system then the arthritis can come on around two to four weeks later, with a respiratory infection with Chlamydia also a possible causative factor. There may be no apparent preceding infection in around ten percent of patients. Many anatomical structures can be affected by the inflammation, including the mucous membrane, the eyes, the joints, the spine, the ligament-bone and tendon-bone junctions and the gastro-intestinal system. Patients with HLAB27 are fifty times more likely to develop reactive arthritis than those without it.
The arthritis can last longer and be more severe if the person has a strong history in the family or they are HLAB27 positive. Of those having an infection of the gut between one and four percent may develop a reactive arthritis, but this varies greatly even with the same biological agent responsible. It is not understood how the host body and the antigen react to cause the arthritic condition and the samples of joint fluids do not exhibit the infectious organisms. Antibodies have been isolated in the joints and it is possible an inflammatory condition mediated by the immune system is implicated in the development of this condition.
The self limiting nature of this kind of arthritis means that the condition settles down over a 3-12 month period whether the severity of the symptoms is greater or lower. The chance of the condition recurring is significant, with a higher incidence if a patient is positive for HLAB27, and a new episode is potentially triggered by infections or other agents. The arthritic process can be mild or can cause destructive and disabling changes in the joints in a small group of fifteen percent of sufferers. The usual age range for onset of this condition is between 20 and 40 years, gut infections giving a 50:50 male to female ratio and urogenital infections giving a 9 to 1 ratio.
Reactive arthritis usually comes on quickly as an acute presentation with patients presenting with tiredness, high temperature and a feeling of being unwell. Lower extremity arthritis of a few joints, arranged non symmetrically (unlike rheumatoid arthritis) is common. Heel pain from inflammation of the insertion of the Achilles tendon into the heel bone is common and low back pain is present in half of the patients. Lower limb joints involved in weight bearing are typically affected, with more severely affected patients exhibiting hands and feet symptoms. Back pain symptoms are commonly reported but examination shows few findings apart from a reduction in lumbar flexion.
Reactive arthritis treatment is determined by how difficult the arthritic symptoms are for the patient, with a mainstay of treatment being non-steroidal anti-inflammatory drugs which are taken regularly to keep up a level of anti-inflammatory action. The maintenance and restoration of muscle power, control of pain and protection of joint ranges of motion can be effected by referral to physiotherapy. Intra-articular injections with corticosteroids are a useful treatment and can give long term relief of an inflamed joint. If anti-inflammatory drugs are not effective then systemic corticosteroids can be given and while antibiotic drugs may be prescribed at times they do not affect the disease course.
Chronic and ongoing joint arthritis and poorly limited inflammatory reactions may mean a rheumatologist will prescribe drugs known as DMARDS or disease modifying anti-rheumatoid drugs. These have been tested on conditions such as rheumatoid arthritis or ankylosing spondylitis but their usefulness in reactive arthritis has not been shown. Typical examples are methotrexate and sulphasalazine. The newer biological drug treatments have been effective in some conditions but have not yet been shown to be useful in this condition.
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More Humira questions please visit : DrugsFreeFAQ.com
Humira injections procces?
– Take a look at the pages on the following website for more information. Source(s): http://www.drugs.com/search.php?searchte?? http://www.humira.com/ this site will give you that information.
I am on the drug Humira?
I am taking humira , basically i can not live with out it. The cost has gone up so high. I am struggling to afford it. INS will not Help and i own good INS. The cost is 00 a month for me. I am wondering if anyone knows of any help sites or medical places that can help…
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I’m romatoidic, I’m treted with Humira injection. I’m 42 please I want the full explain!! I These websites should have all the info you want. Everything from what the injection consists of to every known impulse etc. Hope this helps. www.humira.com www.rxlist.com/humira-drug.htm# http://arthritis.about.com/od/humira/p/h??
Need to know how much is humira?
My Doc wants me to start Humira for RA. Anyone know what the price tag carries with that? – It is ridiculously expensive.if you enjoy health insurance you should call and ask what they’re negotiated contract price is currently. Average prices: https://www.changehealthcare.com/rx_bran?? If you don’t have insurance, appointment the Humira helpline listed…
Why Are the Humira Ads Only Mentioning Hep B, and Not Hep C?
– Humira is used to suppress your immune system to treat autoimmune diseases like rheumatoid arthritis. If a patient is a carrier of Heb B, they are likely to re-activate the virus. With Hep B most general public are either immunized for it or if it’s contracted, they can clear it…
Has anyone developed cancer from taking Humira or Remicade?
I have Psoriatic Arthritis, and currently take 40mg Humira injection once a week, and have been on it for over a year very soon. Prior to that I was on Remicade infussions, and prior to that was Enbrel with Methotrexate. They are now proverb that people who take Humira or Remicade are 2-3 times more…
Is hackle loss a side effect of Humira?
– anyway as we know hair loss can be caused by many different reasons! Find out the actual mete out of hair loss! There are many causes of loss of hair such as stress, poor nutrition ,medication, thyroid dysfunctions, illness, fungal infections ,hormonal problems, to mention a few. year ago I suffered very much from…
Just have biopsy for generous cold thyroid nodule, should i start Humira or hang about?
All the information with photos are available on http://www.cancerssociety.org
Has anyone out here almost died or have an unexplained infection while on humira?
My mother was diagnosed with rheumatoid arthritis (RA) in her early thirties. She is immediately 49 and has been taking Humira for about 1 year. Two days after her last injection, she developed a hallucination of 103.5; four days later she was on life support and the family be…
Which arthritis drugs are cause cancer within youths?
Over the counter drugs are blamed for causing cancer in kids and young adults – These are not over the counter drugs, but ones prescribed for young relations suffering from juvenile rheumatoid arthritis or Crohns disease. The drugs under suspicion are: Remicade (infliximab), Enbrel (etancercept), Humira (adalimumab), Cimzia (certolizumab pegol) and Simponi (golimumab).
Will taking Humira (immunotherapy/biotherapy) affect a people DNA?
Humira is a recombinant DNA product given to crohns patients to change the way the body produces TNF blockers. Nothing in the world can change you DNA. It will other be the same.
I HAVE CROHNS DISEASE AND WAS PUT ON HUMIRA INJECTIONS EVERYOTHER WEEK ALONG WITH MY METHOTRXATE INJECTIONS I GET WEEKLY. I HAVE BEEN GETTING THE HUMIRA SINCE MAY BUT MY SYMPTOMS SEEM TO BE RETURNING .HAS ANY OTHER HUMIRA USERS THAT HAVE CROHNS DISEASE HAD THIS HAPPEN TO THEM. ALSO I WAS WONDERING HOW LONG THE HUMIRA CAN SIT OUT WITH…
Humira Commerical whats the song they play contained by the commerical?
– I haven’t seen the commercial, but answerbag.com said it was “I Will Be” Source(s): http://www.answerbag.com/q_view/137738 http://www.artistdirect.com/cgi-bin/gx.c??
Humira Injections – Psoriatic arthritis?
I was just diagnosed with Fibromyalga & Psoratic arthritis. Has anyone out there be diagnosed with the same, and taken the Humira injections? did they help with. torment, stiffness, skin issues? What did you feel where the drawbacks ?? Are you still taking the injections? thanks ! – I don’t know anyone who…
Humira vs. Remicade for Crohn’s?
Can you please tell me which one works better and which one has fewer side effects. Also, the pain level of humira(having to inject yourself). Base on personal experience or medical stats. Note: Im 14 and I have Crohns Disease. Im taking remicade but I hate to miss school every 6 weeks to sit in a hospital for 2…
I be on Humira and feel ghastly on it is Enbrel any better?
I was on Humira and during the 3 months I was on it I was so tired all the time I could hardly function day to day. I also had a constant headache and felt resembling I had the flu for 3 months. I experience severe weakness in my arms and legs.
I be taking Humira Prefld Syr 0.8ml 2′S for my rheumatoid arthritis but another benifit be it fixed my psori
But the copay is at 0 for a 90 day supply. Are there any other meds that will work the same but cheaper and might be covered by insurance? – My experience with Humira is that theres not really another one approaching it.
I hold be taking Humira for my Psoriatic Arthritis…?
but the injections are extremely painful, how long do I have to stay on them? Is their another option that doesn’t involve an injection or IV? – The main anti-TNF drugs are Enbrel, Remicade, and Humira. And they are adjectives either injected or IV. When you say the injections are painful,…
Anyone here hold experience beside Humira within treating crohn’s disease?
I’m 20 and I’ve had CD for three years and have been on remicade for most of that time every 8 weeks. However, final infusion I had a lot of side effects after for a couple weeks. My doctor wants to try Humira and see how that works for me. Anyone taking or has taken…
Anyone hold experience using Humira injections for Crohn’s disease? Thanks!?
– What does adalimumab injection do? ADALIMUMAB (HumiraTM) is used to help treat rheumatoid arthritis. Adalimumab may help prevent further damage to your bones and joints, and can moderate arthritis symptoms like joint pain and inflammation. Adalimumab may be used with other drugs used to treat rheumatoid arthritis. Adalimumab is usually given…
If I enjoy to pilfer Dmards (Ex. Enbrel, Remicade, Humira, ect.) does that penny-pinching my arthritis is severe?
True, I’m in a lot of pain ALL the time, and it really takes a toll on my natural life, but isn’t this what it’s like for all people with arthritis? – It is possible you have been prescribed this kind of treatment because you…
Is alchohol allowed when taking Humira for RA?
Anyone out there taking Humira? – Yes you can drink alcohol when you take Humira. There are no contraindications or warnings about it. I’ve search everywhere. http://www.humira.com/ 16 pages of prescribing information make no mention of any adverse effects with, or caution against, alcohol. Of course, as other, ask your doctor. Cheers!…
Is Humira a form of chemotherapy?
– Humira is a TNF biologic drug f
or rheumatoid arthritis. TNF stands for Tumor Nucrosis factor. The drug binds with certain protiens in the body so they will stop attacking the body. That is he main use for it. It can also be used for other forms of arthritis, but i know it is market for RA.
Is Humira on the VA medication schedule?
Yes i know i can call the VA – Here you go—Humira (adalimumab). I believe this shows that it was added to the list in Sept. 2003: http://www.pbm.va.gov/monograph/74397ada?? For more info on the prescription drugs on their register: http://www.pbm.va.gov/default.aspx
Is Humira protected for the treatment of Rheumatoid arthritis?
I have RA and i used humira . it worked for me for a little while. But i think she should try it. It might work better for your mother then what it did for me. I immediately use Enrel twice a week and feel much better.
Is in that anyone using Humira Pen and for what bad health? How oodles injections and treatments?
I am using it for a GI problem but don’t think it was meant to treat just GI. The commericals are outstandingly vague, like the Remicade was at first. I am just curious as to the other strength areas it is being used. -…
Are here any Crohn’s pts. taking Humira for fistulas?
For Crohn’s pts. only: how long have you been on it, did you experience any side effects, is it expensive, and anything else you wish to append. thank you. PS: I am a Crohnie & am looking at options I was given. – I too am suffering from fistula’s (I have…
What are side affects of Humira?
The following side effects are associated with Humira SubQ: Common side effects: Bacterial Infection of Blood or Tissues affecting the Whole Body Severe High Blood Pressure Severe Acute Infection of the Nose, Throat or Sinus Severe Bronchitis Severe Urinary Tract Infection Severe Systemic Lupus Erythematosus Severe Abscess Severe Fever Severe …
Where I can find the better price for HUMIRA?
I have and ankylosing spondylitis, and I need to buy Humira for treatment, I live in Chile . I need to find the better place to buy HUMIRA, next to the best price. – Try Canada
Anybody taking Humira for Ankylosing Spondylitis? Was on Remicade…?
Just wandering if anybody had ever switched from Remicade to Humira? Do you have any side effects? I had my first shot today and so far so good,,,,,but I am still worried,,,,I am hoping tommarrow will be a have a feeling good day for me like it was when I be on remicade. – …
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More Respiratory Diseases questions please visit : DiseasesFAQ.com
Am I breathing properly?
Hi, Im 15 and I’ve been smoking for a bit over a year and lately I just feel different similar to im not breathing properly. Like its weird to explain but it just feels similar to i cant breathe in as much as i want to. Maybe its all in my person in charge i don’t know.
Am I experiencing an asthma attack?
I’ve always had asthma since i was a newborn, but I haven’t had an asthma attack since i was about 8 or 9, zing, pain in the throat/chest, dizzyness, vomitting, trouble breathing/shortness of breath I’m not wheezing, & there’s not much torment in my throat but I”m having shortness of breath & i’m dizzy.
Am I getting a cold? Or is it something else?
I have an extremely sore throat. ality really really bad right now ( like not doing anything ) I am sucking on cough drops, but they aren’t helping! Do I own the beginning of a cold? – hey dont worry even a bit. i am pretty sure that it is…
Am I getting sick from my nouns conditioner?
I spend Monday morning – Thursday at my boyfriend’s & then Thursday night through Sunday at my house. He has crucial air at his place that’s kept at 70 degrees & I have an A/C component in my bedroom that’s admittedly on high all the time. I have what I’m pretty sure was…
AM I GOING TO DIE?!?
ok so im a 11 year old girl. and for the last three days everytime AFTER im done eating i carry a horrible stomach ache, and i get diareeha. and i start to feel really tired and purely horrible. i don’t know why and its freaking me out. i don’t have any fever and don’t look…
Am I going to enjoy complications?
this kid who was doing community service was cleaning at the gym I work at and I noticed he be using clorox cleaning spray and then he starting using windex in the same nouns. I started freaking out and said “you can’t do that it will cause damage” If he only used a few sprays…
Am I have a nouns attack?
I feel very strange. All of a sudden, I feel sick, table lamp headed, my legs feel jelly-ish and I have a strange tingling surrounded by my chest. I’m finding it slightly hard to breathe, and feel like I’m going to vomit. Am I have a panic attack? Please help ASAP. I’ve never had one…
Am i have asthma symptoms?
I’ve been sick for about two weeks, I cough and it gets worse at darkness because i cough so much i feel i can’t breathe and end up throwing up. Im not sure if it’s asthma or what. I’ve gone to the doctor but they didn’t really mention anything about it. I’ve get no other symptoms…
Am i have nouns attack?
im not sure if its really a panic attack or sumthing is wrong with me, and this has happen a few times when i go to sleep, i would wake up to rapid breathing, and i would enjoy to take small breathes in and out to calm myself down next afterwords i would have 2 sit…
Am I have some sympathetic of anxiety attack?
i have no clue whats wrong with me equently when my family left me to go out i started sweating and choking on my breath after i started uncontrollably crying and trembling is this something serious? – u could be having an anxiety attack. do u grain like u are…
Am i phsychologically sick?
at nights i imagine stories that when you publish it i may get a fresh anw … so i imagine it and sometimes i talk with my pillow and feat but i have alot of passion in acting its similar to im living in this story … am i sick? – No you are not sick!…
Am I sick or what is wrong beside my throat?
I have had cough for exactly 2 weeks now. All of a sudden I start coughing seriously randomly and I do cough up some mucus. When I look up and stretch my throat it hurts and I start to cough a lot. What do I have? I do not own anything…
Am i sick..or is it something else?
Okay so lately ive decided to give up eating meat and to seize my protean i would eat beans instead and my health teacher said this would be okay and i started this going on for…a week ago. so the Other day i ate like two peaces of grass ( i don’t know why…
Am I sick? I ponder I hold a cold?
I have a sore throat, little coughing and sneezing, clogged/runny nose, feeling hot but a few minutes subsequent I get the chills and a tiny headache. Should I stay home from school tomorrow? – ya – Well I’m no doc or anything but yeah it sounds similar to a cold…
Am I sick? please back!?
I have a headache, chest pain, soar throat, my ear pops when i swallow, coughing, and my legs now hurt.Am i sick? – These things your inkling are called symptoms, definitely you’re sick. Symptoms (Subhanallah) seems to be here for the purpose of telling us we have to seek oblige, go on a Checkup.
Am I sick? please serve!?
i first thought it was just my allergies ( sneezing, runny nose, liquid eyes, and stuffed up nose) but then when i went to sleep and woke up, i was still matching even after i took a medicine pill. the only thing be no sneezing, but now when i swallow i feel like the spinal…
Am I sick??/?
So I have a runny nose and an itchy throat and my throat is red. I dont have a thermometer sorry. Im other feeling dizzy and stuff am i sick? – Is this a prank? e its strept throat or your allergic to something or just coming down with a cold – it might be allergies. maybe…
Am i sick??
hi, the last couple of months i have been getting trunk bleeds every couple of days that last for a minute or two for no reason in different enviroments eg.conservatory, home. then about every month i get one that last 10minutes. why. am i sick p.s. i have not taken any new medicine or anything close to…
Am i smoking too several cigarettes?
Im 16 and i smoke 3 packs of reds a day…my grandma does just as much but my friends just do 1..people piss me off everyday which is why i do it but what is your opinion? – That IS too much. n how to relieve stress in a in good health way. …
Am I The Only Person That’s Constanly Paranoid (Even In The Abscence Of Narcotics)?
You are definitely paranoid. njoy a new President who’s style of presidency seems reassuring but I’m waiting for the other shoe, ya know? We’ve get a severe economic crises where they can spend 750 billion dollars on a bailout but still come up with billions for…
Am I wrong for smoking weed?
So I smoke weed. I have been a smoker for about ten years and not once enjoy I ever been caught with or smoking it. I keep it to myself. In reality, I have many friends, and only around ten percent of them know that I enjoy the pleasures of it. I made eighty-two thousand…
Ammonia and Oxygen!?
4 NH3 (g) + 5 O2 (g) ———–(produce) 4 NO (g) + 6H2O (l) 21.0 mL sample of NH3 gas is allowed to react with excess oxygen at room warmth,25 celcius and 1 atm,calculate the number of molecules of water produced. – moles NH3 = pV / RT = 1 atm x 0.721 L/ 0.08206 x 298…
Amoxicillin what is used for?
Amoxicillin is a broad spectrum antibiotic and can be used in the treatment of infections cause by bacteria. – It is a first line antibiotic to gun down bacterial conditions such as sinusitis, otitis media, oral infections. However, its use is limited do to over prescribing and over-requesting by patients. Thus a higher…
An acute diagnosis is one which begin slowly and last a long time True or False?
Acute means having severe symptoms and a short course. er- False. Source(s): http://en.wikipedia.org/wiki/Acute_(medi… http://en.wikipedia.org/wiki/Chronic_(me… – Those two words don’t belong together. An illness is eith
er acute or chronic. The diagnosis is the medical term for the…
Anatomy Case Study-Your tolerant, a 20 year infirm masculine have a respiratory disease that have literally paralyzed the?
Your patient, a 20 year old male have a respiratory disease that has literally paralyzed the cilia of his trachea. He currently lives with 2 roommates, one who works part time at his family’s daycare center. His labs show that he have a…
Ankylosing spondylitis symptoms – is this conventional?
My husband has recently been diagnosed next to ankylosing spondylitis and has recently said he has a ‘woolly’ lead – there is no pain but he feels a bit spacy sometimes and also keeps dropping things – is this normal? His next appointment is within three months – should he go back earlier?…
Annoying Wet Cough please minister to?
Im am getting really annoyed im recovering from a cold and i now have a wet cough that started yesterday, and i do expel the mucus but its still near. Right now im in school and i can’t hold running to t bathroom to spit this stuff out. help please – It means you…
Anprolene (Ethylene Oxide) Exposure?
I work at a small vet clinic, and we have a gas sterilizer that uses Anprolene. It has a vent that sucks all the gas outside, and it is located surrounded by a room separate from the rest of the clinic. When I went in there the other light of day to look for a…
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“We continue to believe that ARCOXIA has the potential to become a valuable treatment option for many Americans with arthritis and pain,” said Raymond V. Gilmartin, chairman, president and chief executive officer, Merck & Co., Inc. “We plan to work with the FDA to address what steps need to be taken before the application may be approved.”
About ARCOXIA and Merck
The company submitted a revised NDA to the FDA on Dec. 30, 2003, to include efficacy data for ankylosing spondylitis and to provide additional cardiovascular safety data. In the NDA, Merck is seeking indications for ARCOXIA for the treatment of osteoarthritis, rheumatoid arthritis, chronic low back pain, acute pain, dysmenorrhea (menstrual pain), acute gouty arthritis and ankylosing spondylitis.
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ARCOXIA has been launched in 48 countries worldwide in Europe, Latin America and the Asia-Pacific region. Merck will continue to work with regulatory agencies in the countries where ARCOXIA is approved, including the European Medicines Agency which recently announced plans for a safety review of the COX-2s, to assess whether changes to the prescribing information for this class of drugs, including ARCOXIA, are warranted.
Merck & Co., Inc. is a global research-driven pharmaceutical company. Merck discovers, develops, manufactures and markets a broad range of innovative products to improve human and animal health, directly and through its joint ventures.
This press release contains “forward-looking statements” as that term is defined in the Private Securities Litigation Reform Act of 1995. These statements involve risks and uncertainties, which may cause results to differ materially from those set forth in the statements. The forward-looking statements may include statements regarding product development, product potential or financial performance. No forward-looking statement can be guaranteed, and actual results may differ materially from those projected. Merck undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events, or otherwise. Forward-looking statements in this press release should be evaluated together with the many uncertainties that affect Merck’s business, particularly those mentioned in the cautionary statements in Item 1 of Merck’s Form 10-K for the year ended Dec. 31, 2003, and in its periodic reports on Form 10-Q and Form 8-K (if any) which the company incorporates by reference.
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How does Arcoxia work?
Arcoxia is used to treat the pain associated with osteoarthritis, chronic musculoskeletal pain, rheumatoid arthritis, ankylosing spondylitis, and gout. It is utilized to deaden the pain of both the chronic and sudden forms of these arthritic conditions. Arcoxia works primarily through blocking the enzyme COX-2
When will a generic be available for Arcoxia?
There is currently a generic form of Arcoxia available known as Etoricoxib.
How do I use Arcoxia?
The typical usage of Arcoxia is different based on which particular condition the individual is afflicted with. Osteoarthritis sufferers are recommended to use a single dose of 60 mg each day. For those individuals that suffer from rheumatoid arthritis the recommended dosage is generally prescribed as 90 mg once per day. The condition of ankylosing spondylitis also requires a recommended dosage of 90 mg taken once per day. Gout, however requires a singular dosage of Arcoxia once a day with a recommended dosage of 120 mg. Arcoxia should only be taken for gout during the most acute periods of pain. Chronic musculoskeletal pain will require a recommended dosage of 60 mg once per day.
How to buy a generic for Arcoxia?
The generic form of Arcoxia is known as Etoricoxib. Etoricoxib can be purchased at many online distributors and in many pharmacies world wide. The best location to purchase it online is at http://www.thedrugcompany.com/product/arcoxia.
How can I buy Arcoxia online?
The drug Arcoxia can be readily purchased online at http://www.thedrugcompany.com/product/arcoxia.
How to save money on Arcoxia?
The simplest method for aving money on Arcoxia is by purchasing it in bulk online at http://www.thedrugcompany.com/product/arcoxia.
Does Arcoxia help with Arthritis?
Yes, the drug Arcoxia is designed to aid in the treatment of arthritis as well as several other variations of this condition.
Is Arcoxia the same as Etoricoxib?
The answer to this question is twofold. Etoricoxib is the generic form of Arcoxia. Etoricoxib is the primary ingredient in the brand name drug Arcoxia and due to this fact the two drugs perform the same primary function medically. However, they are in fact two separate drugs.
Where can I get information on how to use Arcoxia?
For further information regarding Arcoxia refer to the website http://www.thedrugcompany.com/product/arcoxia. The Drug company is well versed in all forms of this particular drug as well as many other types for sale throughout the world.
How many people are taking Arcoxia?
Arcoxia is an anti-arthritis drug used by millions of people worldwide to aid in the treatment of their arthritic symptoms.
Is cheap Arcoxia available in countries other than the US?
Yes, cost effective and cheap Arcoxia is available worldwide via http://www.thedrugcompany.com/product/arcoxia.
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Conventional drugs are chemically synthesized. Of the four currently licensed biologics, three help reduce inflammation and structural damage of the joints by blocking a substance called tumor necrosis factor (TNF), a protein involved in immune system responses. Elevated levels of TNF are found in the synovial fluid of rheumatoid and some other arthritis patients.
The first biologic to receive FDA approval for patients with moderate-to-severe RA was Enbrel (etanercept). Initially, it was taken twice weekly by injection, but a once-weekly preparation is now available. Enbrel has been shown to decrease pain and morning stiffness and improve joint swelling and tenderness. In 2000, the drug’s approved uses were expanded to include delaying structural damage. Besides RA, Enbrel now has been approved for two other common forms of arthritis: psoriatic arthritis and ankylosing spondylitis.
The two other TNF-blocking products approved to treat RA are Remicade (infliximab) and Humira (adalimumab), a drug that provided the long-awaited relief for Shirley through a 2002 clinical trial. All three TNF blockers have been demonstrated to improve physical function in studies of at least two years in duration.
“While all three inhibit the action of TNF,” says Jeffrey N. Siegel, M.D., team leader for the FDA’s Division of Therapeutic Biological Internal Medicine Products, “they do it in somewhat different ways.” Remicade and Humira are monoclonal antibodies, laboratory-produced proteins similar to those made by a person’s immune system that bind and remove TNF from the body before it can set off the immune reaction responsible for RA.
Enbrel, on the other hand, is a soluble cytokine receptor, which means it is similar in structure to protein molecules found attached to the surface of cells that bind TNF. Enbrel competes with these receptors to inhibit them from binding TNF, thus blocking them from setting off the immune process responsible for RA, psoriatic arthritis, and ankylosing spondylitis.
Siegel warns that caution is important when using these agents as treatments. “All TNF blockers are associated with infection,” he says.
Kineret (anakinra), another biologic approved by the FDA for patients with RA, has been shown in clinical trials to improve pain and swelling and slow the progression of structural damage in patients.
Arthritis Treatment Devices
Two medical device products, Hyalgan and Synvisc, are preparations that mimic a naturally occurring body substance that lubricates the knee joint called hyaluronic acid. The products, which were approved by the FDA for the treatment of OA of the knee, are injected directly into the knee joint to help provide temporary relief of pain and flexible joint movement.
Another device used in arthritis treatment is transcutaneous electrical nerve stimulation (TENS), which has been found effective in modifying pain perception. TENS blocks pain messages to the brain by directing mild electric pulses to nerve endings that lie beneath the painful area of the skin.
A blood-filtering device called the Prosorba Column is used in some cases for filtering out harmful antibodies in people with severe rheumatoid arthritis.
Heat and cold can both be used to reduce the pain and inflammation of arthritis. Patients and their doctors can determine which one works best.
Thanks to the right treatment, Shirley says his pain level today is only about 10 percent of what it once was. “Looking back on those days,” he says, “it’s hard to believe all the things I can do now. I’ve regained mobility and strength.” And once again, Shirley can mow the lawn, cook meals, fix things around his house, and even pursue his favorite hobby of bird watching.
“Rheumatoid arthritis is now an illness for which newer treatments offer the real likelihood of patients being able to pursue a lifestyle without the limitations imposed by joint pain and deformity,” adds Birbara.
Importance of Diet and Exercise
Arthritis experts say there’s value in physical activity, the right diet, and other non-medicinal interventions that can help prevent arthritis, reduce pain, and keep people moving, as emphasized in a 10-year initiative called Healthy People 2010. A comprehensive, nationwide health promotion and disease prevention program developed by the Department of Health and Human Services, Healthy People 2010 contains 467 objectives for improving the nation’s health in conditions such as cancer, sexually transmitted diseases, and arthritis.
Research in 2004, for example, demonstrated that exercise and diet together significantly improve physical function and reduce knee pain in people older than 60 who are overweight or obese, according to both the Arthritis Foundation and the American College of Rheumatology. The results of the study are published in the May 2002 issue of Arthritis & Rheumatism. Similarly, pain and disability accompanying all types of arthritis can be minimized through early diagnosis and appropriate management, including self-management, physical and occupational therapy, joint replacement surgery, weight control, and physical activity.
According to the CDC, research shows that physical activity decreases joint pain, improves function and a person’s mood and outlook, and delays disability. Exercise helps reduce the pain and fatigue of many different kinds of arthritis and helps people work and do daily activities and remain independent. Range-of-motion, strengthening, and endurance exercises, such as moving a joint as far as it will go, using muscles without moving joints, and aerobic exercises, respectively, are beneficial in decreasing fatigue, strengthening muscles and bones, increasing flexibility and stamina, and improving the general sense of well-being.
It’s important that people stay at their recommended weight, especially as they get older, because being overweight makes them more at risk for OA. Extra weight increases the risk for getting OA in the knees and possibly in the hips. This is especially true for women. In men, extra weight increases the risk for getting another common form of arthritis, gout (excess uric acid in the blood), as well. Maintaining a healthy weight and avoiding joint injuries reduces the risk of developing arthritis and decreases disease progression.
Some people claim to have been cured by treatment with herbs, oils, chemicals, special diets, radiation, or other products. According to the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), however, there is no scientific evidence that such treatments cure arthritis. Moreover, some of these unproven treatments may lead to serious side effects. Patients should talk to their doctors before using any therapy that has not been prescribed or recommended by their health care team.
Nearly 300,000 children in the United States have a form of juvenile arthritis or a rheumatic disease that occurs before age 16. The most common form in children is juvenile rheumatoid arthritis. The cause of most forms of juvenile arthritis remains unknown. Juvenile arthritis is not contagious, and there is no evidence that foods, toxins, allergies, or vitamin deficiencies play a role. Current research indicates that there may be a genetic predisposition to juvenile arthritis. In other words, the combination of genes a child inherits may contribute to the development of arthritis when combined with other undefined factors. Most of the symptoms of juvenile arthritis are due to inflammation as a result of imbalances in the immune system. Despite not knowing the exact cause or causes, there are many effective treatments available to help children and their parents manage juvenile arthritis. Experts say that most children with arthritis can expect to live normal lives.
Many government and private organizations are working together to carry out a plan to guide the use of the nation’s resources to decre
ase the burden of arthritis for all Americans and increase the quality of life of those affected by arthritis. Called the “National Arthritis Action Plan: A Public Health Strategy,” it provides a blueprint for reducing pain, activity limitations, and disability among people with arthritis, as well as for preventing certain types of arthritis.
As for the safety of future arthritis treatments, experience has shown that the full magnitude of some potential risks of all drugs has not always emerged during the mandatory safety and effectiveness studies conducted before the FDA can approve a drug. As always, the agency advises physicians to consider the evolving information on any medication in evaluating the risks and benefits of these drugs in individual patients.
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Maybe pain occurs, like when trying to open a jar. What’s it all about? Let’s look at the basics and learn more.
Arthritis actually means “joint inflammation” and has over 100 related conditions or type / forms of disease. Left untreated, it can advance, resulting in joint damage that cannot be undone or reversed. So early detection and treatment are important.
The two most common types of arthritis are osteoarthritis (OA) and rheumatoid arthritis (RA). Although both have similar symptoms, both happen for different reasons. When joints are overused and misused, the results can be OA. What happens is that the cushioning cartilage that protects the joint breaks down, resulting in the bones rubbing together. This generally happens in the knees, but can be found in the hips, spine and hands often, too. And only in later stages will a person most often feel pain, after quite a bit of cartilage is lost.
The second type, RA, refers to the body’s immune system attacking joint tissue. Still not fully understood in the medical community, this condition most often starts in a person’s hands, wrists and feet. Then it advances to shoulders, elbows and hips.
Similar symptoms include pain, stiffness, fatigue, weakness, slight fever and inflamed tissue lumps under the skin. And both OA and RA generally develop symmetrically, i.e. affecting the same joints on both the left and right sides of the body.
A difference in OA and RA to note is with swelling. With RA, people report “soft and squishy” swelling. While with OA, people report “hard and bony” swelling. Another difference is that a person is more likely to develop RA if a sibling or parent had it. While a person with a history of joint damage, either an injury or chronic strain, runs a higher risk for developing OA.
There is no specific age for arthritis sufferers. While it can affect every age group, it seems to focus on those over 45 years of age.And while neither gender is immune, a reported 74 percent of OA cases (or just over 15 million) occur with women and a slightly lower percentage of RA cases occur with women. People with excess weight tend to develop OA, especially in the knees when reaching over 45 years of age. However, losing weight can turn the odds around almost by half. Regular activity combined with exercise also reduces risk, strengthening joint muscles and reducing joint wear.
Although there are no cure-alls for arthritis, there are a variety of pain relief treatment strategies. Aside from medications, remedies, replacement alternatives and other helpful treatment options and alternatives, the four main arthritis relief aids are gentle exercise, good nutrition, a positive attitude and rest. And each will be discussed further in subsequent sections, because education can play a huge role to dispel “old wives tales” and myths that “nothing can be done about arthritis.” Notable is that today, only a small percentage of those afflicted with arthritis become crippled. And most never need canes, wheelchairs, or other ambulatory devices.
Also note if you suspect you may have arthritis, it is advisable to seek medical advice. Because healthcare providers can help to determine if the symptoms are not something else like a virus or tendonitis or other similar problem that cold potentially worsen if left untreated.
Types Of Arthritis
There are many ways to effectively manage arthritic pain today to find relief. Available are arthritic diets, exercise programs, over-the-counter and prescription medications, relaxation and positive emotion coping techniques. Also available are surgeries, supplements, home remedies, natural and other alternative therapies. When arthritis is first suspected, it would be wise to seek a medical opinion first. Then as time and resources allow, check out the other options.
After osteoarthritis (OA) and rheumatoid arthritis (RA), three other major types of arthritis are systemic lupus erythematosis, ankylosing spondylitis and gout. Let’s take a look at each:
Systemic Lupus Erythematosis (SLE) – This form of arthritis mainly affects women. It develops in the skin, internal organs and joints.
Ankylosing Spondylitis – This form or arthritis affects the spine and can also affect the ankles, knees, lungs, heart, shoulders and eyes.
Gout – This is a painful affliction mainly for men, about one million of them in the United States alone. Uric acid build up, due to an internal chemical malfunction, forms crystals that get stuck in a joint, generally the big toe, and become inflamed.
Science Of Arthritis
Joints can handle some heavy pressure. For example, knees handle a force of three to four times a person’s total body weight on average just talking a walk. The force of a deep knee bend during a squat can increase to nine times the body weight. So just imagine multiplying weight of more than 150 pounds times a minimum of three or four, and then even more. That can sure add up to a lot of heavy work on knee joints over time.
Now for the science of this scenario. Where two bones meet, called the joint, the bone ends are covered with cartilage, also known as gristl
This cartilage is sturdy, elastic and spongy or compressible, and keeps the bones from moving against each other at the joint. The cells of this cartilage, called chondrocytes, are thought to be the longest living cells of the body. Surrounding the bones and cartilage is strong, fibrous capsule lined with synovium, a thin membrane that lubricates the joint area with fluid. The end result is less friction or smoother rubbing together of the bones. This fluid also feds the cartilage cells, keeping them healthy, and is “pumped” into them during joint movement. Thus lack of movement (activity / exercise) can be unhealthy.
Other parts of the body features involved with this arthritic scenario include muscles, tendons, ligaments, bursea and mental activity. Muscles, attached to bones with tendons and ligaments, move bones by contracting. They also cushion movement, absorbing impact or shock. Throughout the muscle and tendon areas are bursae or sacs filled with fluid. These also help cushion movement. And throughout all the coordination of these parts during movement, the brain is a part. The brain communicates via nerves throughout the body, in particular the muscles for this scenario, to prepare joints for activity.
The exact science of what actually causes arthritis is still being researched. For most of the 100-plus forms of arthritis, the causes are unknown. Injury, overuse of joints and mechanical issues with joints (like skeletal abnormalities, worn out joint muscles) can lead to arthritis. And many point to issues relating to bacteria and germs as some of the problem. Heredity, stress, drugs, food allergies and viruses have also been linked to some forms of arthritis. So have diet, poor circulation and lack of movement.
Arthritic joints can be affected with inflammation when bacteria or a virus (or other undesirable element) enters the joint area or when an injury occurs. What happens is when foreign matter enters this area or the area sustains injury, white blood cells, antibodies and other natural “fighting” mechanisms automatically kick in internally to help. These fighters cause swelling, redness and heat as the body fluid moves around. Symptoms of inflammation, one of the uncomfortable issues associated with arthritis, are redness, swelling and tender joints.
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Arthritis refers to a group of over 100 different conditions which involves damage to the joints of the body. The disease affects more women than men. Arthritis can also affect other parts of the body causing pain, loss of movement and swelling. One of the most prevalent chronic health problems in the United States, arthritis is also one of the main causes of work disability in the country. It affects people of all ages including children.
In 2006, the number of American people with arthritis or chronic joint symptoms was about 46 million, nearly 20% of the adult population.
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Arthritis can be of various types. The most prevalent form of the disease is osteoarthritis, a degenerative joint disease in which the cartilage covering the ends of bones in the joint undergoes decay, which causes pain and loss of movement because bones rub against each other. In rheumatoid arthritis, which is an autoimmune disease, the joint lining becomes inflamed as part of activity of the body’s immune system. This disease affects mostly women, and causes serious disability.
Gout, which affects mostly men, is a painful disease that affects small joints, especially the big toe. However, gout can be brought under complete control using appropriate drugs and proper diet. There is also an uncommon form of gout called psedogout caused by the formation of rhomboid crystals of calcium pyrophosphate. Ankylosing spondylitis is a kind of arthritis in which the bones of the spine grow together because of inflammation. Juvenile arthritis is a general term that includes all types of arthritis that occur in children.
Children may develop juvenile rheumatoid arthritis or childhood forms of lupus, ankylosing spondylitis or other types of arthritis. Another type of arthritis is fibromyalgia that affects mostly women. It causes stiffness and pain in the tissues that support and move the bones and joints. Systemic lupus erythematosus or lupus is also a serious disorder that inflame and damages joints and other connective tissues throughout the body. Scleroderma, a condition linked with the connective tissue, causes a thickening and hardening of the skin.
Arthritis symptoms include pain, swelling and stiffness in joints or the inability to move a joint normally. In rheumatoid arthritis, joints can become red, warm, swollen and painful making a person feel sick. Among other symptoms are unexplained fatigue, fever, loss of weight and swollen lymph glands. Symptoms often last more than two weeks. Arthritis is diagnosed on the basis of the pattern of symptoms, medical and family history, physical examination, X-rays, laboratory tests etc.
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Back pain is an all-too-familiar problem that can range from a dull, constant ache to a sudden, sharp pain that leaves you incapacitated. It can come on suddenly—from an accident, a fall, or lifting something heavy—or it can develop slowly, perhaps as the result of age-related changes to the spine. Regardless of how back pain happens or how it feels, you know it when you have it. And chances are, if you don’t have back pain now, you will eventually.
“Weekend warriors”—people who go out and exercise a lot after being inactive all week—are more likely to suffer painful back injuries than people who make moderate physical activity a daily habit. Studies show that low-impact aerobic exercise is good for the disks that cushion the vertebrae, the individual bones that make up the spine.
Diet: A diet high in calories and fat, combined with an inactive lifestyle, can lead to obesity, which can put stress on the back.
Heredity: Some causes of back pain, such as ankylosing spondylitis, a form of arthritis that affects the spine, have a genetic component.
Race: Race can be a factor in back problems. African American women, for example, are two to three times more likely than white women to develop spondylolisthesis, a condition in which a vertebra of the lower spine—also called the lumbar spine—slips out of place.
The presence of other diseases: Many diseases can cause or contribute to back pain. These include various forms of arthritis, such as osteoarthritis and rheumatoid arthritis, and cancers elsewhere in the body that may spread to the spine.
Occupational risk factors: Having a job that requires heavy lifting, pushing, or pulling, particularly when this involves twisting or vibrating the spine, can lead to injury and back pain. An inactive job or a desk job may also lead to or contribute to pain, especially if you have poor posture or sit all day in an uncomfortable chair.
Cigarette smoking: Although smoking may not directly cause back pain, it increases your risk of developing low back pain and low back pain with sciatica. (Sciatica is back pain that radiates to the hip and/or leg due to pressure on a nerve.) For example, smoking may lead to pain by blocking your body’s ability to deliver nutrients to the disks of the lower back. Or repeated coughing due to heavy smoking may cause back pain. It is also possible that smokers are just less physically fit or less healthy than nonsmokers, which increases the likelihood that they will develop back pain. Smoking also increases the risk of osteoporosis, a condition that causes weak, porous bones, which can lead to painful fractures of the vertebrae. Furthermore, smoking can slow healing, prolonging pain for people who have had back pain.
What Are the Causes of Back Pain?
It is important to understand that back pain is a symptom of a medical condition, not a diagnosis itself. Medical problems that can cause back pain include the following:
Mechanical problems: A mechanical problem is a problem with the way your spine moves or the way you feel when you move your spine in certain ways. Perhaps the most common mechanical cause of back pain is a condition called intervertebral disk degeneration, which simply means that the disks located between the vertebrae of the spine are breaking down with age. As they deteriorate, they lose their cushioning ability. This problem can lead to pain if the back is stressed. Other mechanical causes of back pain include spasms, muscle tension, and ruptured disks, which are also called herniated disks.
Injuries: Spine injuries such as sprains and fractures can cause either short-lived or chronic pain. Sprains are tears in the ligaments that support the spine, and they can occur from twisting or lifting improperly. Fractured vertebrae are often the result of osteoporosis. Less commonly, back pain may be caused by more severe injuries that result from accidents or falls.
Acquired conditions and diseases: Many medical problems can cause or contribute to back pain. They include scoliosis, a curvature of the spine that does not usually cause pain until middle age; spondylolisthesis; various forms of arthritis, including osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis; and spinal stenosis, a narrowing of the spinal column that puts pressure on the spinal cord and nerves. Although osteoporosis itself is not painful, it can lead to painful fractures of the vertebrae. Other causes of back pain include pregnancy; kidney stones or infections; endometriosis, which is the buildup of uterine tissue in places outside the uterus; and fibromyalgia, a condition of widespread muscle pain and fatigue.
Infections and tumors: Although they are not common causes of back pain, infections can cause pain when they involve the vertebrae, a condition called osteomyelitis, or when they involve the disks that cushion the vertebrae, which is called diskitis. Tumors also are relatively rare causes of back pain. Occasionally, tumors begin in the back, but more often they appear in the back as a result of cancer that has spread from elsewhere in the body.
Although the causes of back pain are usually physical, emotional stress can play a role in how severe pain is and how long it lasts. Stress can affect the body in many ways, including causing back muscles to become tense and painful.
Can Back Pain Be Prevented?
One of the best things you can do to prevent back pain is to exercise regularly and keep your back muscles strong. Exercises such as tai chi and yoga—or any weight-bearing exercise that challenges your balance—are good ones to try.
Eating a healthy diet also is important. For one thing, eating to maintain a healthy weight—or to lose weight, if you are overweight—helps you avoid putting unnecessary and injury-causing stress and strain on your back. To keep your spine strong, as with all bones, you need to get enough calcium and vitamin D every day. These nutrients help prevent osteoporosis, which is responsible for a lot of the bone fractures that lead to back pain. Calcium is found in dairy products; green, leafy vegetables; and fortified products, like orange juice. Your skin makes vitamin D when you are in the sun. If you are not outside much, you can obtain vitamin D from your diet: nearly all milk and some other foods are fortified with this nutrient. Most adults don’t get enough calcium and vitamin D, so talk to your doctor about how much you need per day, and consider taking a nutritional supplement or a multivitamin.
Practicing good posture, supporting your back properly, and avoiding heavy lifting when you can may all help you prevent injury. If you do lift something heavy, keep your back straight. Don’t bend over the item; instead, lift it by putting the stress on your legs and hips.
When Should I See a Doctor for Pain?
In most cases, it is not necessary to see a doctor for back pain because pain usually goes away with or without treatment. However, a trip to the doctor is probably a good idea if you have numbness or tingling, if your pain is severe and doesn’t improve with medication and rest, or if you have pain after a fall or an injury. It is also important to see your doctor if you have pain along with any of the following problems: trouble urinating; weakness, pain, or numbness in your legs; fever; or unintentional weight loss. Such symptoms could signal a serious problem that requires treatment soon.
What Is the Difference Between Acute and Chronic Pain?
Pain that hits you suddenly—after falling from a ladder, being tackled on the football field, or lifting a load that is too heavy, for example—is acute pain. Acute pain comes on quickly and often leaves just as quickly. To be classified as acute, pain should last no longer than 6 weeks. Acute pain is the most common type of back pain.
Chronic pain, on the other hand, may come on either quickly or slowly, and it lingers a long time. In general, pain that lasts longer than 3 months is considered chronic. Chronic pain is much less common than acute pain.
Mr. Schuett recommends: Get more than one diagnosis – not all doctors think alike. Do your research – know what to ask. Don’t be afraid to ask. After all, IT’S YOUR BACK.
Just sharing my experiences and thoughts about AS
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